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A two-week gap separated every two courses, during which tamoxifen citrate (40 mg per day) and clomiphene citrate (10 mg per day) were taken to control serum testosterone levels. The first two courses were given at the end of the test. Testosterone levels returned to baseline during the third interval, and the fourth interval followed the second interval. After both intervals, a three-month washout period ended. The next testosterone dose was taken at the completion of the third interval. An analysis of the cumulative testosterone dose for the entire study period (December 2011 to December 2012) was carried out. The second and third intervals are included in the analysis. Table 1 shows the estimated changes in testosterone levels from baseline to the end of the study. The average change was +6.2 μg per milliliter. The average change in baseline serum testosterone levels was +1.3 nmol per liter. At the end of the study, the mean baseline and mean change in testosterone levels were +5.6 and +7.7 nmol per liter, respectively. Table 1 Testosterone values at end of study Discussion The present study reveals that low-dose tamoxifen used orally and intramuscularly is able to decrease serum testosterone concentrations; however, its effects on luteinizing hormone levels were less clear. The combination of tamoxifen and clomiphene citrate, in comparison with tamoxifen and clomiphene citrate alone, resulted in statistically significant decreases in testosterone levels during the study interval. Moreover, it is clear that the combined combination of tamoxifen and clomiphene citrate decreased luteinizing hormone levels. Although the observed effects of tamoxifen-clomiphene citrate treatment on testosterone levels with a relatively long lag period were not statistically significant, these differences should be taken into account when comparing tamoxifen and clomiphene with other steroid-based inhibitors. Tamoxifen and clomiphene both increase plasma testosterone levels in the low to moderate doses (Table 2)17. However, in the present study the higher dosage (400 mg/day) of tamoxifen produced a statistically significant improvement of luteinizing hormone levels, suggesting a possible benefit of tamoxifen on luteinizing hormone secretion from the anterior pituitary. In the present study, an improvement in blood testicular size did not reveal a significant effect of tamoxifen on luteinizing hormone, probably because of the low dose, which did not alter the blood parameters. The present study suggests that tamoxifen use reduces luteinizing Related Article:

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